葛慎光

學(xué)歷/學(xué)位

研究生/博士

職稱/職務(wù)

教授、A5崗

聯(lián)系電話

0531-82767161

電子郵箱

chm_gesg@ujn.edu.cn

實(shí)驗(yàn)室/辦公室

逸夫科學(xué)樓B-204

主講課程

分析化學(xué)、新型功能材料、分光光度分析

科研方向：

1.功能納米材料制備、納米與生物分子的相互作用

2.生物傳感器的構(gòu)建及應(yīng)用、傳感器信號(hào)轉(zhuǎn)換與放大新原理和新方法

3.微流控紙芯片性能調(diào)控和傳感機(jī)制研究、器件的開(kāi)發(fā)和研制

4.電化學(xué)分析、光致電化學(xué)分析、比色分析、熒光分析及熒光成像

科研成果及獎(jiǎng)勵(lì)（包括項(xiàng)目、專利、鑒定等）（2005年以來(lái)）：

主持項(xiàng)目：

1.國(guó)家自然科學(xué)基金面上項(xiàng)目-紙芯片甄別檢測(cè)高侵襲惡性循環(huán)腫瘤細(xì)胞的新方法-(21775055）

2.國(guó)家自然科學(xué)基金面上項(xiàng)目-基于中空通道紙芯片的自推進(jìn)分離捕獲循環(huán)腫瘤細(xì)胞及原位分析-(No.21575051)

3.國(guó)家自然科學(xué)基金青年基金-基于點(diǎn)擊化學(xué)的微囊藻毒素化學(xué)傳感器構(gòu)建-（No.21207048)

4.山東省自然科學(xué)基金-功能化石墨烯電化學(xué)傳感器的構(gòu)建及其在免疫學(xué)中應(yīng)用-（No.ZR2011BQ019）

5.山東省自然科學(xué)基金/省屬高校優(yōu)秀青年基金-多功能紙芯片分離捕獲外周血中腫瘤細(xì)胞及原位分析-（No.ZR2015JL006）

6.山東省科技發(fā)展計(jì)劃-研制紙芯片器件對(duì)水體中農(nóng)藥殘留的檢測(cè)與監(jiān)控-（No. 2014GGX103012）

7.濟(jì)南市青年科技明星計(jì)劃-含反應(yīng)基團(tuán)的Si/C/N陶瓷前驅(qū)體聚硅氮烷的制備及性能研究-（No.20110102）

8.中國(guó)科學(xué)院環(huán)境化學(xué)與生態(tài)毒理學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室開(kāi)放基金-基于紙微芯片的電化學(xué)發(fā)光免疫分析研究-（No.KF2011-03）

9.濟(jì)南大學(xué)博士基金-紙微芯片上電致化學(xué)發(fā)光行為研究-（No.XBS1428）

第一發(fā)明人授權(quán)發(fā)明專利：

1.檢測(cè)痕量農(nóng)藥殘留物的分子印跡化學(xué)發(fā)光傳感器及其應(yīng)用-（發(fā)明專利：ZL200910018139.8）

2.檢測(cè)痕量農(nóng)藥殘留物的電致化學(xué)發(fā)光傳感器的制備及應(yīng)用-（發(fā)明專利：ZL 201010507594.7）

3.水泥材料自修復(fù)的分子自組裝微球制備及應(yīng)用-（發(fā)明專利：ZL201010524199.X）

4.一種基于點(diǎn)擊化學(xué)仿生分子印跡電化學(xué)傳感器的制備及對(duì)食品過(guò)敏原的檢測(cè)-（發(fā)明專利：201210472177.2）

5.用于葉酸過(guò)表達(dá)癌細(xì)胞快速檢測(cè)的比色方法-（發(fā)明專利：201410124906.4)

6.一種電聚合分子印跡聚合物中空通道紙器件的制備及在農(nóng)藥殘留即時(shí)檢測(cè)中的應(yīng)用-（發(fā)明專利：201410436014.8）

教學(xué)成果與獎(jiǎng)勵(lì)（2005年以來(lái)）：

科技獎(jiǎng)勵(lì)：

1.基于結(jié)構(gòu)調(diào)控和光電性能的紙芯片微流控基礎(chǔ)研究與傳感機(jī)制，山東省自然科學(xué)獎(jiǎng)一等獎(jiǎng)。

2.紙芯片傳感器納米材料構(gòu)建傳感界面和實(shí)現(xiàn)信號(hào)放大，山東省高等學(xué)校優(yōu)秀科研成果獎(jiǎng)一等獎(jiǎng)。

3.基于新型發(fā)光試劑和傳感器設(shè)計(jì)的高選擇性發(fā)光分析研究，山東省高等學(xué)校優(yōu)秀科研成果獎(jiǎng)一等獎(jiǎng)。

4.紙芯片傳感器納米材料構(gòu)建傳感界面和實(shí)現(xiàn)信號(hào)放大，濟(jì)南大學(xué)優(yōu)秀科研成果一等獎(jiǎng)。

5.新型熒光試劑的合成及在分析中應(yīng)用，濟(jì)南大學(xué)優(yōu)秀科研成果二等獎(jiǎng)。

6.新型熒光探針的設(shè)計(jì)及在環(huán)境檢測(cè)中的研究，濟(jì)南大學(xué)優(yōu)秀科研成果三等獎(jiǎng)。

7.含共軛結(jié)構(gòu)的有機(jī)硅聚合物的制備及應(yīng)用，山東省科技進(jìn)步獎(jiǎng) 三等獎(jiǎng)。

8.新型多功能聚硅氮烷的開(kāi)發(fā)及應(yīng)用研究，中國(guó)石油和化學(xué)工業(yè)聯(lián)合會(huì) 三等獎(jiǎng)。

9.新型含氮聚硅烷的制備與應(yīng)用，中國(guó)建筑材料聯(lián)合會(huì) 科技進(jìn)步二等獎(jiǎng)。

10.微流控紙芯片的功能調(diào)控技術(shù)及其應(yīng)用，中國(guó)石油與化學(xué)工業(yè)聯(lián)合會(huì) 二等獎(jiǎng)。

代表性論文（2005年以來(lái)）：

1 Linlin Liang, Feifei Lan,Shenguang Ge*, Jinghua Yu, Na Ren, and Mei Yan, Metal-Enhanced Ratiometric Fluorescence/Naked Eye Bimodal Biosensor for Lead Ions Analysis with Bifunctional Nanocomposite Probes, Analytcial Chemistry, 2017, 89, 3597?3605.

2Shenguang Ge,? Lina Zhang,? Yan Zhang, Feifei Lan, Mei Yan, Jinghua Yu*,Nanomaterials Modified Cellulose Paper as a Platform for Biosensing Application, nanoscale, 2017, 9, 4366-4382

3Shenguang Ge?, Feifei Lan?, Linlin Liang, Na Ren, Li Li, Haiyun Liu, Mei Yan, Jinghua Yu*, Ultrasensitive Photoelectrochemical Biosensing of Cell Surface N-glycan Expression Based on the Enhancement of Nanogold-assembled Mesoporous Silica Amplified by Graphene Quantum Dots and hybridization Chain Reaction, ACS Applied Materials & Interfaces, 2017,9(8), 6670-6678.

4 Xiaolu Sun, Chaomin Gao, Lina Zhang, Mei Yan, Jinghua Yu,Shenguang Ge*，Photoelectrochemical sensor based on molecularly imprinted film modified hierarchical branched titanium dioxide nanorods forchlorpyrifosdetection，Sensors & Actuators: B. Chemical,2017,251, 1-8.

5.Linlin Liang, Feifei Lan, Xuemei Yin,Shenguang Ge^*, Jinghua Yu, Mei Yan, Metal-Enhanced Fluorescence/Visual Bimodal Platform forMultiplexedUltrasensitive Detection of MicroRNA with Reusable Paper Analytical Devices, Biosensors and Bioelectronics, 2017, 95, 181–188

6 Feifei Lan, Guoqiang Sun, Linlin Liang,Shenguang Ge*, MeiYan, JinghuaYu, Microfluidic paper-based analytical device for photoelectrochemical immunoassay with multiplex signal amplification using multibranched hybridization chain reaction and PdAu enzyme mimetics, Biosensors and Bioelectronics, 2016, 79, 416–422.

7Shenguang Ge, Kaiqing Wu, Yan Zhang, Mei Yan, Jinghua Yu*, Paper-based biosensor relying on flower-like reduced graphene guided enzymatically deposition of polyaniline for Pb²⁺detection, Biosensors and Bioelectronics, 2016, 80, 215-221.

8 Linlin Liang, Min Su, Li Li, Feifei Lan, Guangxin Yang,Shenguang Ge*, Jinghua Yu, Xianrang Song, Aptamer-based fluorescent and visual biosensor for multiplexed monitoring of cancer cells in microfluidic paper-based analytical devices, Sensors & Actuators: B. Chemical, 2016, 229,347-354.

9 Haiyun Liu, Lina Zhang, Meng Li, Mei Yan, Mei Xue, Yan Zhang, Min Su, Jinghua Yu,Shenguang Ge*,Electrochemiluminescence-molecular logic gates based on MCNTs for the multiplexed analysis of mercury (II) and silver (I) ions，RSC Advances, 2016, 6, 26147 – 26154

10 Linlin Liang, Feifei Lan, Li Li, Min Su,Shenguang Ge*, Jinghua Yu, Haiyun Liu, Mei Yan, Fluorescence “turn-on” determination of H2O2 using multilayer porous SiO2/NGQDs and PdAu mimetics enzymatic/oxidative cleavage of single-stranded DNA, Biosensors and Bioelectronics, 2016, 82, 204–211.

11Shenguang Ge, Linlin Liang, Feifei Lan, Yan Zhang, Yanhu Wang, Mei Yan, Jinghua Yu*, Photoelectrochemical Immunoassay Based on Chemiluminescence as Internal Excited Light Source, Sensors and Actuators: B，2016, 234, 324-331.

12 Linlin Liang, Feifei Lan, Li Li,Shenguang Ge*, Jinghua Yu, Na Ren, Haiyun Liu, Mei Yan, Paper Analytical Devices for Dynamic Evaluation of Cell Surface N-Glycan Expression via a Bimodal Biosensor Based on Multibranched Hybridization Chain Reaction Amplification, Biosensors and Bioelectronics, 2016, 86: 756-763.

13Shenguang Ge, Feifei Lan, Feng Yu, Jinghua Yu*, Applications of Graphene and Related Nanomaterials in Analytical Chemistry, New Journal of Chemistry, 2015, 39, 2380--2395.

14Shenguang Ge, Lina Zhang, Jinghua Yu*, Paper-based microfluidic devices in bioanalysis:how far have we come?, Bioanalysis, 2015, 7(6), 633-636.

15Shenguang Ge, Weiping Li, Mei Yan, Xianrang Song and Jinghua Yu, Photoelectrochemical Detection of Tumor Marker Based on CdS Quantum Dots/ZnO Nanorods/Au@Pt-Paper Electrode 3D Origami Immunodevice, Journal of Materials Chemistry B, 2015, 3, 2426–2432.

16Shenguang Ge, Yan Zhang, Lina Zhang, Linlin Liang, Mei Yan, Jiadong Huang, Jinghua Yu,* and Mingwei Sun,Ultrasensitive Electrochemical Determination of Cancer Cells Based on TrimetallicDendritic Au@PtPdNanoparticles for Signal Amplification on Lab-on-Paper Device,Sensors and Actuators: B，2015, 220, 665-672.

17 Long Li, Lina Zhang, Jinghua Yu,Shenguang Ge*, Xianrang Song*,All-Graphene Composite Materials for Signal Amplification toward Ultrasensitive ElectrochemicalImmunosensing of Tumor Marker, Biosensors and Bioelectronics, 2015, 71, 108-114.

18Shenguang Ge, Yan Zhang, Lina Zhang, Haiyun Liu, Jiadong Huang, Mei Yan, Jinghua Yu,^*Electrochemical K-562 Cells Sensor Based on Origami Paper Device for Point-of-care Testing, Talanta, 2015,145,12-19.

19 Lei Ge, Min Su, Xutang Tao*,Shenguang Ge*, Application of Au cage/Ru(bpy)32+ nanostructures for the electrochemiluminescence detection of K562 cancer cells based on aptamer, Sensors and Actuators: B. 2015, 214, 144–151 .

20 Shenguang Ge, Weiyan Liu, Haiyun Liu, Fang Liu, Jinghua Yu, Mei Yan*, Jiadong Huang*，Colorimetric detection of the flux of hydrogen peroxide released from living cells based on the high peroxidase-like catalytic performance of porous PtPd nanorods, Biosensors and Bioelectronics, 2015, 71, 456-462.

21 Guoqiang Sun, Hongmei Yang, Yan Zhang, Jinghua Yu,Shenguang Ge*, Mei Yan, Xianrang Song, Branched zinc oxide nanorods arrays modified paper electrode for electrochemical immunosensing by combining biocatalytic precipitation reaction and competitive immunoassay mode, Biosensors and Bioelectronics, 2015, 74, 823–829.

22Shenguang Ge, Fang Liu, Weiyan Liu, Mei Yan, Xianrang Song and Jinghua Yu，Colorimetric assay of K-562 cells based on folic acid-conjugated porous bimetallic Pd@Au nanoparticles for point-of-care testing，Chem. Commun., 2014, 50, 475-477.

23Shenguang Ge, Mingwei Sun, Weiyan Liu, Shuai Li, Xiu Wang, Chengchao Chu, Mei Yan, Jinghua Yu, Disposable electrochemical immunosensor based on peroxidase-like magnetic silica–graphene oxide composites for detection of cancer antigen 153, Sensors and Actuators B, 2014, 192, 317–326.

24Shenguang Ge, Lei Ge, Mei Yan, Xianrang Song, Jinghua Yu, Shanshan Liu, A disposable immunosensor device for point-of-care test of tumor marker based on copper-mediated amplification,Biosensors and Bioelectronics,2013, 43, 425-431.

25Shenguang Ge, Weiyan Liu,Lei Ge, Mei Yan, Jixian Yan, Jiadong Huang, Jinghua Yu，In Situ Assembly Porous Au-paper Electrode and Functionalization ofMagnetic Silica Nanoparticleswith HRP via Click Chemistry for Microcystin-LR Immunoassay，Biosensors and Bioelectronics, 2013, 49, 111–117.

26Shenguang Ge, Lei Ge, Mei Yan, Xianrang Song, Jinghua Yu* and Jiadong Huang, A Disposable Paper-based Electrochemical Sensor with Addressable Electrode Array for Cancer Screening,Chem. Commun., 2012, 48 (75), 9397 – 9399.

27 Mei Yan#,Shenguang Ge#, Weiqiang Gao, Chengchao Chu, Jinghua Yu, Xianrang Song, Fluorescence Immunosensor Based on p-acid encapsulated Silica Nanoparticles for Tumor Marker Detection, Analyst, 2012, 137 (12), 2834 - 2839.

28Shenguang Ge, Mei Yan, Juanjuan Lu, Meng Zhang, Feng Yu, Jinghua Yu, Xianrang Song, Shilin Yu, ElectrochemicalBiosensor Based on Graphene Oxide–Au Nanoclusters Composites forL-CysteineAnalysis.Biosensors and Bioelectronics, 2012, 31, 49-54.

29Shenguang Ge, Xiuling Jiao, Dairong Chen,Ultrasensitive Electrochemical Immunosensor for CA 15-3 Using Thionine-Nanoporous Gold-Graphene as Platform and Horseradish Peroxidase-Encapsulated Liposome as Signal Amplification,Analyst, 2012,137, 4440-4447.

30Shenguang Ge, Feng Yu, Lei Ge, Mei Yan, Jinghua Yu, Dairong Chen, Disposable Electrochemical Immunosensor for Simultaneous Assay the Panel of Breast Cancer Tumor Markers, Analyst,2012, 137 (20), 4727 - 4733.